Search results for " PV12 cells"

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DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis

2019

Docosahexaenoic acid (DHA) is an omega‑3 polyunsaturated fatty acid, derived mainly from fish oil. It is well known that DHA is present in high concentrations in nervous tissue and plays an important role in brain development and neuroprotection. However, the molecular mechanisms underlying its role remain to be fully elucidated. In this study, to enhance our understanding of the pathophysiological role of DHA, we investigated the possible neuroprotective mechanisms of action of DHA against hydrogen peroxide (H2O2)‑induced oxidative damage in a rat pheochromocytoma cell line (PC12). Specifically, we evaluated the viability, oxidation potential, and the expression and production of antioxida…

0301 basic medicineAnimals; Apoptosis; Docosahexaenoic Acids; Glutathione Peroxidase; Heme Oxygenase-1; Hydrogen Peroxide; NF-E2-Related Factor 2; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Superoxide DismutaseAntioxidantDocosahexaenoic AcidsSettore BIO/14 - FARMACOLOGIADHA neuroprotection PV12 cellsNF-E2-Related Factor 2medicine.medical_treatmentApoptosismedicine.disease_causePC12 CellsNeuroprotectionSuperoxide dismutase03 medical and health scienceschemistry.chemical_compound0302 clinical medicinedecosahexaenoic acidGeneticsmedicineAnimalschemistry.chemical_classificationGlutathione PeroxidasebiologySuperoxide DismutaseChemistryGlutathione peroxidasenuclear factorHydrogen PeroxideGeneral MedicineAscorbic acidMalondialdehydeNFE2L2RatsCell biologyOxidative StressNeuroprotective Agents030104 developmental biology030220 oncology & carcinogenesisbiology.proteinHeme Oxygenase-1Oxidative stressInternational Journal of Molecular Medicine

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